Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition
نویسندگان
چکیده
منابع مشابه
Profiling of Substrate Specificity of SARS-CoV 3CLpro
BACKGROUND The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-coronavirus is required for autoprocessing of the polyprotein, and is a potential target for treating coronaviral infection. METHODOLOGY/PRINCIPAL FINDINGS To obtain a thorough understanding of substrate specificity of the protease, a substrate library of 198 variants was created by performing saturation mutagenes...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2010
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2010.09.035